Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Tocris Bioscience™ T3
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Offers one or more environmental benefits itemized in the U.S. FTC Green Guides.
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Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells
Tocris Bioscience™ Gefitinib-based PROTAC™ 3
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Potent EGFR PROTAC™
R&D Systems™ Cy5-Fuc Labeled Glycan G2f
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Tocris Bioscience™ Kinesore
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Kinesin-1 modulator; cell permeable
| CAS | 363571-83-9 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H16Br2N4O4 |
| Formula Weight | 536.17 |
Tocris Bioscience™ VH 032 amide-PEG5-acid
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VHL ligand with PEG linker and terminal acid for onward chemistry
Tocris Bioscience™ 4-Octyl Itaconate
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Nrf2 activator; cell permeable
| CAS | 3133-16-2 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 2-Methylenebutanedioic acid 4-octyl ester |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C13H22O4 |
| Formula Weight | 242.31 |
Tocris Bioscience™ ML 162
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Inhibits glutathione peroxidase (GPX4); induces ferroptosis
| Target | Glutathione Peroxidase 4/GPX4 |
|---|---|
| CAS | 1035072-16-2 |
| Purity | 0.98 |
| Chemical Name or Material | 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C23H22Cl2N2O3S |
| CAS | 5234-68-4 |
|---|---|
| Molecular Formula | C12H13NO2S |
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Tocris Bioscience™ SPRi 3
Tocris Bioscience™ SPRi 3
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Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR); attenuates proliferation of CD4+ T cells
| CAS | 1292285-54-1 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C14H18N2O3 |
| Formula Weight | 262.3 |
| CAS | 160003-66-7 |
|---|---|
| Molecular Formula | C7 H5 I N2 O3 |
Tocris Bioscience™ EPZ 015666
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Potent and selective PRMT5 inhibitor
| CAS | 1616391-65-1 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H25N5O3 |
| Formula Weight | 383.44 |
Tocris Bioscience™ PF 06651600 malonate
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Potent and selective JAK3 inhibitor
| CAS | 2140301-97-7 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C15H19N5O.C3H4O4 |
Tocris Bioscience™ CHDI 00390576
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Potent and selective class IIa HDAC inhibitor; brain penetrant
Tocris Bioscience™ SIM1
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Potent and selective trivalent BET Bromodomain Degrader (PROTAC™)